Computational Materials Science
|Coluzza, Ivan||Ikerbasque Research Professor|
Prof. Coluzza worked in world leading biophysics groups and created an extensive network of collaborators. He graduated in physics from La Sapienza University in Rome and obtained his doctorate in physics from the University of Amsterdam. Prof. Coluzza worked as a postdoctoral researcher at the University of Cambridge and at the Institute for Medical Research in London. He recently held the post of assistant at the University of Vienna and Group leader at the CIC biomaGUNE research centre in San Sebastián (Spain). He currently has a position as Professor Ikerbasque at BCMaterials, where he is the head of the Computational Biophysics group.
Prof. Coluzza’s research focuses on the applications of statistical mechanics to soft matter and complex biological systems. During his research experience he developed a deep interest in many different fields ranging from physics to biology.
Computational Biophysics’s research is in the unique position of creating a conceptual bridge between biology and material science.
Computational Biophysics’s discoveries about the crucial role of the hydrogen bond interactions for protein designability reconciled 30 years of protein modelling with the state-of-the-art full-atomistic protein models. We developed a novel multiscale representation of proteins by progressively reducing their complexity to the bare minimum. Our research showed that directional interactions alone reduce the conformational space of any polymer (including proteins), allowing the possibility of encoding a specific structure in their sequence. We refer to such polymers as Bionic Proteins. Using such a model, we could tackle fundamental biophysical problems such as protein design, folding, evolution and protein-polymer mixtures. For example, we patented smart-nanopores that, by mimicking chaperones, can refold denatured proteins. For more details check our webpage.
|Infante, Ivan Antonio Carlo||Ikerbasque Research Professor|