Establishment of an in vitro platform to quantify the immune response to biomaterials

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BCMaterials – Basque Center for Materials, Applications and Nanostructures is a research center included in the BERC’s (Basque Excellence Research Centers) network, devoted to generate knowledge on the new generation of materials, and turning this knowledge into (multi)functional solutions and devices for the benefit of society, is currently calling for a

 

Predoctoral Researcher position

 

to work on

 

Establishment of an in vitro platform to quantify the immune response to biomaterials

 

The newly established Biomaterials group at BCMaterials (Campus Leioa) focuses on the investigation of the influence of the protein interface, i.e. the protein layer that is deposited on medical implants either voluntarily during the production of biomaterials or by their adsorption from the blood after implantation, on the reaction of the host’s stromal and immune cells. The ultimate goal of the group is to develop new bioengineered replacement materials that control protein deposition to promote optimal integration of the implanted materials into the host tissue.

 

Macrophages are among the first cells to contact biomaterials after implantation, and their response is central to the successful healing of the injury. With this in mind, the PhD project will focus on the establishment of the experimental conditions to investigate the modulation of macrophage polarization in response to a number of biomaterial properties ranging from structural organization and chemical composition to biophysical properties. To this end, the PhD student will apply a multidisciplinary approach involving cell culture, gene expression analysis, immunodetection and protein biochemistry to define the characteristics that favour a well-regulated macrophage response.

 

The following techniques, instruments and facilities will be used:

 

Multidisciplinary approach involving cell culture, gene expression analysis, immunodetection and protein biochemistry to define the characteristics that favour a well-regulated macrophage response.

 

The ultimate goal for the Project is:

 

Establishment of the experimental conditions to investigate the modulation of macrophage polarization in response to a number of biomaterial properties ranging from structural organization and chemical composition to biophysical properties

 

BCMaterials offers a contract, with an enrolment in the PhD program in the University of the Basque Country (UPV/EHU), in collaboration with the Department of Cell Biology and Histology – Faculty of Medicine and Nursing/UPV/EHU Research Group (https://www.ehu.eus/es/web/bch-zbh/home), belonging to the Faculty of Science and Technology (FCT/ZTF) at the University of the Basque Country (UPV/EHU).

 

BCMaterials is committed to equality of opportunity and values diversity.

 

This position is part of the Call for PhD Fellowships published on BCMaterials website at https://www.bcmaterials.net/training/phd-program/ with the reference (2020-09), therefore, the terms and conditions of the call apply. Candidates must meet the general eligibility criteria stated on it, and fill the application form at the end of this page, including their CV, academic records and motivation and reference letters.

 

Before applying, candidates are encouraged to get in touch with researchers in charge of the project, in order to obtain detailed information about it:

 

  • Director (UPV/EHU): Lucia Jimenez-Rojo (lucia.jimenez@ehu.es)
  • Co-director (BCMaterials): Unai Silvan (un@isilvan.com)

 

All the applicants will be contacted by BCMaterials through a supplied email, as soon as the call is closed.

 

Selected publications:

 

  1. Schoenenberger AD et al., Biomaterials. 2020, 249:120034. doi: 10.1016/j.biomaterials.2020.120034.
  2. Horvath AN et al., ACS Appl Mater Interfaces. 2019, 11(44):41791-41798. doi: 10.1021/acsami.9b12430.
  3. Razafiarison T et al., Proc Natl Acad Sci U S A. 2018, 115(18):4631-4636. doi: 10.1073/pnas.1704543115.
  4. Schoenenberger AD et al., Acta Biomater. 2018, 71:306-317. doi: 10.1016/j.actbio.2018.03.004.
  5. Razafiarison T et al., Adv Healthc Mater. 2016, 5(12):1481-92. doi: 10.1002/adhm.201600128.