Differentiation of mesenchymal stem cells for cartilage tissue engineering: Individual and synergetic effects of three-dimensional environment and mechanical loading

by / Monday, 22 February 2016 / Published in

Differentiation of mesenchymal stem cells for cartilage tissue engineering: Individual and synergetic effects of three-dimensional environment and mechanical loading


Published in: Acta Biomaterialia,
IN PRESS
Publisher URL: http://www.sciencedirect.com/science/article/pii/S174270611630037X
DOI: http://doi.org/10.1016/j.actbio.2016.01.037 Authors:
J. A. Panadero Senentxu Lanceros-Mendez J. L. Gómez Ribelles
Abstract:

Chondrogenesis of dedifferentiated chondrocytes and mesenchymal stem cells is influenced not only by soluble molecules like growth factors, but also by the cell environment itself. The latter is achieved through both mechanical cues – which act as stimulation factor and influences nutrient transport – and adhesion to extracellular matrix cues – which determine cell shape. Although the effects of soluble molecules and cell environment have been intensively addressed, few observations and conclusions about the interaction between the two have been achieved. In this work, we review the state of the art on the single effects between mechanical and biochemical cues, as well as on the combination of the two. Furthermore, we provide a discussion on the techniques currently used to determine the mechanical properties of materials and tissues generated in vitro, their limitations and the future research needs to properly address the identified problems.

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